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KMID : 0383819900370040419
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Tuberculosis and Respiratory Diseases
1990 Volume.37 No. 4 p.419 ~ p.427
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Acute Massive Pulmonary Embolism Improved by rt-PA Thrombolytic Therapy -Two Cases of Report-
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남귀현
최동철/정희순/김영환/한성구/심영수/김건열/한용철/남귀현
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Abstract
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Acute massive pulmonary embolism is a serious disease with high mortality rate if
proper management is delayed. Thrombolytic therapy is indicated to correct the
hemodynamic derangement. Urokinase and streptokinase are conventional drugs for this
purpose, but their nonspecific systemic fibrinolytic activation can cause serious bleeding.
Recombinant tissue type Plasminogen Activator (rt-PA) activates fibrin-bound
plasminogen selectively, and is advocated as a local thrombolytic activator without
systemic side effect. But there is little clinical experience on the usage of rt, PA in
acute massive pulmonary embolism.
We report two cases of acute massive pulmonary embolism improved obviously after
rt-PA thrombolytic therapy together with review of literatures.
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KEYWORD
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